Notes: MK-212 is an agonist of the serotonin (5-HT) receptor subtype 5-HT2C (EC50 = 0.028 µM in a calcium mobilization assay).{58910} It is selective for 5-HT2C over 5-HT2A receptors (EC50 = 0.42 µM). MK-212 reduces food intake in fasted rats with an ED50 value of 5 mg/kg.{58911} It reduces cocaine-primed reinstatement of cocaine-seeking behavior in rats when administered at doses of 0.32, 0.56, or 1 mg/kg.{58912}