MK-5108, CAS 1010085-13-8

Shelf life (days): 1460.0

Formulation: A crystalline solid

Formal Name: trans-4-(3-chloro-2-fluorophenoxy)-1-[[6-(2-thiazolylamino)-2-pyridinyl]methyl]-cyclohexanecarboxylic acid

Purity: ≥95%

Formula Markup: C22H21ClFN3O3S

Formula Weight: 461.9

CAS Number: 1010085-13-8

Notes: The Aurora kinases are a family of serine/threonine kinases that are key regulators of mitosis and cytokinesis. MK-5108 is a potent inhibitor of Aurora A (IC50 = 0.064 nM).{30910} It less potently inhibits Aurora B and Aurora C (IC50s =14 and 12 nM, respectively). MK-5108 blocks cell cycle progression and induces apoptosis in a diverse range of human tumor types.{30910,30911} It is effective in vivo, inhibiting the growth of xenograft tumors in mice.{30910}

• SKU: CAY19167-1
• Manufacturer: Cayman Chemical
• Manufacturer SKU: 19167-1
• Package Unit: 1 mg
• Quantity Unit: STK