MK-8617, CAS 1187990-87-9

Product Description: MK-8617 is an orally active pan-inhibitor of hypoxia-inducible factor prolyl hydroxylase 1-3 (HIF PHD1-3) with an IC50 of 1 nM for PHD2.

Applications: COVID-19-immunoregulation

Formula: C24H21N5O4

References: [1]Debenham JS, et al. Discovery of N-[Bis(4-methoxyphenyl)methyl]-4-hydroxy-2-(pyridazin-3-yl)pyrimidine-5-carboxamide (MK-8617), an Orally Active Pan-Inhibitor of Hypoxia-Inducible Factor Prolyl Hydroxylase 1-3 (HIF PHD1-3) for the Treatment of Anemia. J Med Chem. 2016 Dec 22;59(24):11039-11049.

CAS Number: 1187990-87-9

Molecular Weight: 443.45

Compound Purity: 99.92

Research Area: Inflammation/Immunology

Solubility: DMSO : 5.71 mg/mL (ultrasonic;warming;heat to 60°C)

Target: HIF/HIF Prolyl-Hydroxylase

• SKU: MEXHY-101023-10.1
• Manufacturer: MedChemExpress
• Manufacturer SKU: HY-101023-10.1
• Package Unit: 10 mM/1 ml
• Quantity Unit: STK