ML-180, CAS 863588-32-3

Shelf life (days): 1460.0

Formulation: A crystalline solid

Formal Name: 6-[4-(3-chlorophenyl)-1-piperazinyl]-3-cyclohexyl-2,4(1H,3H)-pyrimidinedione

Purity: ≥98%

Formula Markup: C20H25ClN4O2

Formula Weight: 388.9

CAS Number: 863588-32-3

Notes: ML-180 is an inverse agonist of liver receptor homolog-1 (LRH-1, IC50 = 3.7 µM) with maximum efficacy of 64% repression.{24526} It is inactive at the related steroidogenic factor-1 transcriptional activator.{24526} Through LRH-1, ML-180 alters the expression of haptoglobin and serum amyloid proteins A1 and A4, induces the death of estrogen-receptor negative MDA-MB-231 breast cancer cells, and inhibits the steroidogenic acute regulatory promoter (IC50 = 2.05 µM).{24526}

• SKU: CAY15181-1
• Manufacturer: Cayman Chemical
• Manufacturer SKU: 15181-1
• Package Unit: 1 mg
• Quantity Unit: STK