Shelf life (days): 1460.0
Formulation: A crystalline solid
Formal Name: (2R)-N-[4-(4-methoxyphenyl)-2-thiazolyl]-1-[(4-methylphenyl)sulfonyl]-2-piperidinecarboxamide
Purity: ≥95%
Formula Markup: C23H25N3O4S2
Formula Weight: 471.6
CAS Number: 1401242-74-7
Notes: Potassium (K+) channels are categorized by their mode of activation and the number of transmembrane segments.{24547} The voltage-gated six-transmembrane K+ channels include KCNQ1, first recognized for its role in cardiac function and subsequently in hearing, gastrointestinal chloride secretion, and other processes.{24547,24548} ML-277 is a potent activator of KCNQ1 channels (EC50 = 260 nM).{24545} The EC50 value of this compound at the related channels KCNQ2, KCNQ4, and hERG exceeds 30 µM.{24545} ML-277 potentiates both homomultimeric KCNQ1 channels and unsaturated heteromultimeric (KCNQ1/KCNE1) channels in model cardiomyocytes and augments delayed rectifier K+ current in cultured human cardiomyocytes.{24546}
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