ML 297, CAS 1443246-62-5

Product Description: ML 297 (VU 0456810) is a potent and selective GIRK1/2 activator, with an EC50 of 0.16 μM. ML 297 is potential for the treatment of epilepsy[1][2].

Applications: Neuroscience-Neuromodulation

Formula: C17H14F2N4O

References: [1]Wen W, et al. Discovery of 'molecular switches' within a GIRK activator scaffold that afford selective GIRK inhibitors. Bioorg Med Chem Lett. 2013 Aug 15;23(16):4562-6./[2]Kaufmann K, et al. ML297 (VU0456810), the first potent and selective activator of the GIRK potassium channel, displays antiepileptic properties in mice. ACS Chem Neurosci. 2013 Sep 18;4(9):1278-86.

CAS Number: 1443246-62-5

Molecular Weight: 328.32

Compound Purity: 99.14

Research Area: Neurological Disease

Solubility: DMSO : 250 mg/mL (ultrasonic)

Target: Potassium Channel

• SKU: MEXHY-110192-10.1
• Manufacturer: MedChemExpress
• Manufacturer SKU: HY-110192-10.1
• Package Unit: 10 mM/1 ml
• Quantity Unit: STK