Shelf life (days): 1460.0
Formulation: A crystalline solid
Formal Name: N-(4-chloro-2,5-dimethoxyphenyl)-5-cyclopropyl-3-isoxazolecarboxamide
Purity: ≥98%
Formula Markup: C15H15ClN2O4
Formula Weight: 322.7
CAS Number: 912798-42-6
Notes: Signal transducer and activator of transcription 3 (STAT3) is a cytokine-inducible transcription factor with roles in inflammation and cancer.{7286,11981} ML-115 is an isoxazole carboxamide that acts as a cell-permeable STAT3 activator (EC50 = 2 nM) and is more than 28,000-fold selective for STAT3 over STAT1 and NF-κB.{29820} It shows no cytotoxicity against HT-1080 or NIH-3T3 cells. ML-115 increases the expression of BCL3, a known STAT3-dependent oncogene, and enhances STAT3 activation by the pro-inflammatory cytokine IL-6.{29820} As the maintenance of pluripotency in mouse embryonic stem cells requires continued activation of STAT3, ML-115 may be useful in maintaining embryonic stem cells in an undifferentiated state.{29820}
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