Product Description: ML216 (CID-49852229) is a potent, selective and cell permeable inhibitor of the DNA unwinding activity of BLM helicase with IC50s of 2.98 μM and 0.97 μM for BLMfull-length and BLM636-1298, respectively. ML216 inhibits ssDNA-dependent ATPase activity of BLM with a Ki of 1.76 μM. Antitumor avtivity[1][2].
Applications: Cancer-programmed cell death
Formula: C15H9F4N5OS
References: [1]Nguyen GH, et al. A small molecule inhibitor of the BLM helicase modulates chromosome stability in human cells. Chem Biol. 2013 Jan 24;20(1):55-62./[2]Banerjee T, et al. A new development in DNA repair modulation: discovery of a BLM helicase inhibitor. Cell Cycle. 2013 Mar 1;12(5):713-4.
CAS Number: 1430213-30-1
Molecular Weight: 383.32
Compound Purity: 99.89
Research Area: Cancer
Solubility: DMSO : 20 mg/mL (ultrasonic)
Target: DNA/RNA Synthesis
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