MLN-4760, CAS 305335-31-3

MLN-4760, CAS 305335-31-3
SKU
MEXHY-19414-10.1
Packaging Unit
10 mM/1 ml
Manufacturer
MedChemExpress

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Product Description: MLN-4760 is a potent and selective human ACE2 inhibitor (IC50, 0.44 nM), with excellent selectivity (>5000-fold) versus related enzymes including human testicular ACE (IC50, >100 μM) and bovine carboxypeptidase A (CPDA; IC50, 27 μM).

Applications: COVID-19-anti-virus

Formula: C19H23Cl2N3O4

References: [1]Dales NA, et al. Substrate-based design of the first class of angiotensin-converting enzyme-related carboxypeptidase (ACE2) inhibitors. J Am Chem Soc. 2002 Oct 9;124(40):11852-3./[2]Joshi S, et al. Angiotensin converting enzyme versus angiotensin converting enzyme-2 selectivity of MLN-4760 and DX600 in human and murine bone marrow-derived cells. Eur J Pharmacol. 2016 Mar 5;774:25-33./[3]Bennion DM, et al. Activation of the Neuroprotective Angiotensin-Converting Enzyme 2 in Rat Ischemic Stroke. Hypertension. 2015 Jul;66(1):141-8.

CAS Number: 305335-31-3

Molecular Weight: 428.31

Compound Purity: 99.93

Research Area: Cardiovascular Disease

Solubility: DMSO : 8.33 mg/mL (ultrasonic)

Target: Angiotensin-converting Enzyme (ACE)
More Information
SKU MEXHY-19414-10.1
Manufacturer MedChemExpress
Manufacturer SKU HY-19414-10.1
Package Unit 10 mM/1 ml
Quantity Unit STK
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