MM11253, CAS 345952-44-5

Product Description: MM11253 is a potent and selective RARγ antagonist with an IC50 of 44 nM. MM11253 has lower inhibition of RARα, RARβ and RXRα. MM11253 blocks the growth inhibitory effects of RARγ-selective agonists[1][3].

Applications: Cancer-programmed cell death

Formula: C28H30O2S2

References: [1]M I Dawson, et al. Retinoic acid (RA) receptor transcriptional activation correlates with inhibition of 12-O-tetradecanoylphorbol-13-acetate-induced ornithine decarboxylase (ODC) activity by retinoids: a potential role for trans-RA-induced ZBP-89 in ODC inhibition. Int J Cancer. 2001 Jan 1;91(1):8-21./[2]Q Le, et al. Modulation of retinoic acid receptor function alters the growth inhibitory response of oral SCC cells to retinoids. Oncogene. 2000 Mar 9;19(11):1457-65.

CAS Number: 345952-44-5

Molecular Weight: 462.67

Compound Purity: 98.64

Research Area: Cancer

Solubility: DMSO : 125 mg/mL (ultrasonic)

Target: RAR/RXR

• SKU: MEXHY-108530-10.1
• Manufacturer: MedChemExpress
• Manufacturer SKU: HY-108530-10.1
• Package Unit: 10 mM/1 ml
• Quantity Unit: STK