Shelf life (days): 1460.0
Formulation: A solid
Formal Name: N-([1,1'-biphenyl]-4-ylsulfonyl)-D-phenylalanine
Purity: ≥99%
Formula Markup: C21H19NO4S
Formula Weight: 381.4
CAS Number: 193807-58-8
Notes: MMP-2/MMP-9 inhibitor I is a potent inhibitor of matrix metalloproteinase-2 (MMP-2) and MMP-9 (IC50s = 310 and 240 nM, respectively).{32343} It acts by binding zinc at the active site of these MMPs. MMP-2/MMP-9 inhibitor I is active in vivo as well as in vitro and blocks MMP-2/MMP-9-dependent invasion, tumor growth, and metastasis in both cell culture and mouse tumor models.{32343} This compound has been used to elucidate the roles of MMP-2 and MMP-9 in diverse systems, including mammary epithelial cell transformation, neuronal dysfunction, lymphocyte recruitment, and progressive hereditary kidney disease.{32340,32341,32342,32344}
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