Mofezolac, CAS 78967-07-4

Shelf life (days): 1460.0

Formulation: A solid

Formal Name: 3,4-bis(4-methoxyphenyl)-5-isoxazoleacetic acid

Purity: ≥98%

Formula Markup: C19H17NO5

Formula Weight: 339.34202

CAS Number: 78967-07-4

Notes: Mofezolac is an inhibitor of COX-1 (IC50 = 14 nM).{57979} It is selective for COX-1 over COX-2 (IC50 = 440 nM). Mofezolac (1 µg/ml) protects against LPS-induced cell death in BV-2 microglia. In vivo, mofezolac (6 mg/kg, i.p.) reduces hippocampal microglial activation and prostaglandin E2 (PGE2; Item No. 14010) production in a mouse model of LPS-induced neuroinflammation. It reduces phenylquinone-induced writhing in a mouse model of acute pain.{57980} Dietary administration of mofezolac (1,200 ppm) reduces the number of aberrant crypt foci and tumors in a rat model of beef tallow diet-induced colon carcinogenesis.{57981}

• SKU: CAY34102-10
• Manufacturer: Cayman Chemical
• Manufacturer SKU: 34102-10
• Package Unit: 10 mg
• Quantity Unit: STK
• Application: Reinstoffe