Clone Number: GrB-7
Immunogen: Unknown or proprietery to MONOSAN and/or its suppliers
Concentration: 100 ug/ ml
Format: Protein G purified
Storage buffer: PBS with 0.1% BSA and 0.1% sodium azide
Additional info: The antibody reacts with the 33 kD human serine protease granzyme B. It does not react with human granzyme A. It is used as a marker for NK-cells and activated cytotoxic T-cells (CTL). This protease is localized in cytoplasmic granules and gives a granular staining pattern. Granzyme B is involved in target cell apoptosis during lymphocyte mediated cyto-toxicity. Exocytosis of granzyme containing granules in the cytoplasm of the target cell will lead to induction of DNA fragmentation and apoptosis of the target cell.
Applications: ICC, ELISA, IHC-P
References: Kummer, J.A et al. J. Immunol. Methods 1993; 163: 77/Kummer, J.A et al.Clin. Exp. Immunol. 1995;100: 164/de Bruin, P.C. et al. Blood 1994; 84: 3785-3791
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