Target: DENND4C
Conjugate: ATTO 488
Product Type: Monoclonal
Clone Number: 3E8
Immunogen: Full Length Human Recombinant Dennd4c protein
Swiss-Prot: Q5VZ89
Purification: Protein G Purified
Storage Buffer: 640.91mM DMSO, 136.36mM Ethanolamine, 9.09mM Sodium Bicarbonate in 90.9% PBS
Concentration: 1mg/ml
Specificity: Detects ~213 kDa.
Cellular Localization: Cell membrane / Cytoplasm / Cytoplasmic vesicle / Membrane
Tissue Specificity: Widely expressed
Scientific Background: Dennd4c is a guanine nucleotide exchange factor (GEF) for Rab10, and required for GLUT4 translocation (1). It is associated with Alkuraya-Kucinskas Syndrome and Koolen-De Vries Syndrome (2) and interacts with the retromer (3).
References: 1. Sano, H. et al. (2011). J Biol Chem. 286(19):16541-5.2. https://www.genecards.org/cgi-bin/carddisp.pl?gene=DENND4C3. McMillan, K. et al. (2016). J Cell Biol. 214(4):4389–402
Field of Use: Not for use in humans. Not for use in diagnostics or therapeutics. For in vitro research use only.
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