Shelf life (days): 1460.0
Formulation: A crystalline solid
Formal Name: N-methyl-4-(phenylmethoxy)-1-piperidineethanamine, dihydrochloride
Purity: ≥98%
Formula Markup: C15H24N2O / 2HCl
Formula Weight: 321.3
CAS Number: 2095432-59-8
Notes: MS049 is a potent and selective inhibitor of PRMT4 (IC50 = 34 nM) and PRMT6 (IC50 = 43 nM).{32050} It is less active against additional type I PRMTs (IC50s = >130, >220, and 1.6 µM for PRMT1, PRMT3, and PRMT8, respectively) and displays no inhibition against type II or type III PRMTs nor any additional methyltransferases or nonepigenetic targets tested.{32050} MS049 has been shown to reduce the H3R2me2a mark in HEK293 cells with an IC50 value of 0.97 µM and also, unexpectedly, to reduce H4R3me2a in HEK293 cells.{32050} For more information on MS049 please visit the Structural Genomics Consortium (SGC). The negative control, MS049N, for MS049 is also available exclusively through the SGC. You can submit a request to receive the negative control here.
English
Deutsch
