MS37452, CAS 423748-02-1

Shelf life (days): 1460.0

Formulation: A crystalline solid

Formal Name: 1-[4-(2,3-dimethoxybenzoyl)-1-piperazinyl]-2-(3-methylphenoxy)-ethanone

Purity: ≥98%

Formula Markup: C22H26N2O5

Formula Weight: 398.5

CAS Number: 423748-02-1

Notes: Chromobox homolog 7 (CBX7) functions through its N-terminal chromodomain, which recognizes histone 3 trimethyl lysine 27 (H3K27me3), to repress gene transcription. It plays a key role in gene transcription in cellular processes related to stem cell self-renewal and differentiation, as well as tumor progression.{28450} MS37452 is a competitive inhibitor of CBX7 chromodomain binding to H3K27me3 (Ki = 43 µM).{28450} At 250 µM, it has been shown to derepress transcription of the polycomb repressive complex target gene p16/CDKN2A in prostate cancer cells.{28450}

• SKU: CAY17533-1
• Manufacturer: Cayman Chemical
• Manufacturer SKU: 17533-1
• Package Unit: 1 mg
• Quantity Unit: STK