Shelf life (days): 1460.0
Formulation: A solid
Formal Name: 5-[2-[5-chloro-2-[[(5-ethoxy-8-quinolinyl)sulfonyl]amino]phenyl]ethynyl]-4-methoxy-2-pyridinecarboxylic acid
Purity: ≥95%
Formula Markup: C26H20ClN3O6S
Formula Weight: 538.0
CAS Number: 2445185-57-7
Notes: MSC4381 is an inhibitor of monocarboxylate transporter 4 (MCT4; Ki = 0.011 µM).{69857} It selectively inhibits lactate efflux in MDA-MB-231 cells, which endogenously express high levels of MCT4, over SNU-398 cells, which endogenously express high levels of MCT1, and RT4 cells, which endogenously express MCT2 and MCT3 (IC50s = 0.001, >4, and 0.638 µM, respectively). MSC4381 (30 mg/kg) increases survival and reduces tumor volume in an MC-38 murine colorectal carcinoma model when administered in combination with an antibody targeting programmed cell death ligand 1 (PD-L1).{69858}
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