Shelf life (days): 1460.0
Formulation: A solid
Formal Name: 6-(1,3-dihydro-4-hydroxy-6-methoxy-7-methyl-3-oxo-5-isobenzofuranyl)-4-methyl-4E-hexenoic acid, 2-(4-morpholinyl)ethyl-1,1,2,2-d4 ester
Purity: ≥99% deuterated forms (d1-d4)
Formula Markup: C23H27D4NO7
Formula Weight: 437.51902
CAS Number: 1132748-21-0
Notes: Mycophenolate mofetil-d4 is intended for use as an internal standard for the quantification of mycophenolate mofetil (Item No. 13988) by GC- or LC-MS. Mycophenolate mofetil is a prodrug form of mycophenolic acid (Item No. 21716).{37581,37582,37583} It is converted to mycophenolic acid via carboxylesterase 1 (CES1) and CES2.{57837} Mycophenolate mofetil (1 and 10 µg/ml) inhibits thymidine incorporation in primary rat aortic smooth muscle cells.{63370} In vivo, mycophenolate mofetil (12.5 mg/kg) increases the duration of transplant motor activity in a rabbit model of retroperitoneal heterotopic heart transplantation.{37581} It eliminates formation of microbleeds and hemorrhages in the cerebrum of stroke-prone spontaneously hypertensive rats when administered at a dose of 25 mg/kg.{37582} Mycophenolate mofetil (60 mg/kg) also lowers mean arterial pressure (MAP) and reduces urinary albumin excretion and glomerulosclerosis, markers of renal damage, in a mouse model of systemic lupus erythematosus (SLE).{37583}
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