Product Description: Peroxisome proliferator-activated receptors (PPARs) play an important role in regulating lipid and glucose metabolism, and oleoylethanolamide (OEA) is a natural ligand for PPARα. N-Octadecyl-N'-propyl-sulfamide is an analog of OEA and a potent activator of PPARα, with selective binding affinity for PPARα (EC50=100 nM, compared to 120 nM for OEA). N-Octadecyl-N'-propyl-sulfamide (10 mg/kg; ip) inhibits food intake and reduces body weight gain in rats. At a dose of 1 mg/kg, N-Octadecyl-N'-propyl-sulfamide induces satiety, thereby reducing food intake, body weight, and plasma triglyceride concentrations in free-feeding Wistar rats and obese Zucker (fa/fa) rats.
Applications: Metabolism-protein/nucleotide metabolism
Formula: C21H46N2O2S
References: [1]de Fonseca, et al. An anorexic lipid mediator regulated by feeding. Nature 414(6860), 209-212 (2001).
CAS Number: 925891-74-3
Molecular Weight: 390.67
Research Area: Metabolic Disease
Target: Endogenous Metabolite;PPAR
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