Product Description: N1-methyl-pseudouridine (1-Methylpseudouridine), a methylpseudouridine, outperforms 5 mC and 5 mC/N1-methyl-pseudouridine in translation. N1-methyl-pseudouridine in mRNA enhances translation through eIF2α-dependent and independent mechanisms by increasing ribosome density[1].
Applications: COVID-19-immunoregulation
Formula: C10H14N2O6
References: [1]Svitkin YV, et al. N1-methyl-pseudouridine in mRNA enhances translation through eIF2α-dependent and independent mechanisms by increasing ribosome density. Nucleic Acids Res. 2017 Jun 2;45(10):6023-6036./[2]Andries O, et al. N(1)-methylpseudouridine-incorporated mRNA outperforms pseudouridine-incorporated mRNA by providing enhanced protein expression and reduced immunogenicity in mammalian cell lines and mice. J Control Release. 2015 Nov 10;217:337-44./[3]Nance KD, Meier JL. Modifications in an Emergency: The Role of N1-Methylpseudouridine in COVID-19 Vaccines. ACS Cent Sci. 2021;7(5):748-756.
CAS Number: 13860-38-3
Molecular Weight: 258.23
Compound Purity: 99.97
Research Area: Inflammation/Immunology
Solubility: DMSO : 100 mg/mL (ultrasonic)/H2O : 50 mg/mL (ultrasonic)
Target: DNA/RNA Synthesis;Nucleoside Antimetabolite/Analog
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