Naporafenib, CAS 1800398-38-2

Product Description: Naporafenib (LXH254) is a potent, selective, orally active, type II BRAF and CRAF inhibitor, with IC50 values of 0.072 and 0.21 nM against CRAF and BRAF, respectively[1][2].

Applications: Cancer-Kinase/protease

Formula: C25H25F3N4O4

References: [1]CAPONIGRO, Giordano, et al. THERAPEUTIC COMBINATIONS COMPRISING A RAF INHIBITOR AND A ERK INHIBITOR. WO 2018051306 A1 20180322/[2]Kelli-Ann Monaco, et al. LXH254, a Potent and Selective ARAF-Sparing Inhibitor of BRAF and CRAF for the Treatment of MAPK-Driven Tumors. Clin Cancer Res. 2021 Apr 1;27(7):2061-2073.

CAS Number: 1800398-38-2

Molecular Weight: 502.49

Compound Purity: 99.86

Research Area: Cancer

Solubility: DMSO : 100 mg/mL (ultrasonic)

Target: Bcr-Abl;p38 MAPK;Raf

• SKU: MEXHY-112089-10.1
• Manufacturer: MedChemExpress
• Manufacturer SKU: HY-112089-10.1
• Package Unit: 10 mM/1 ml
• Quantity Unit: STK