Necrostatin-7, CAS 351062-08-3

Shelf life (days): 1460.0

Formulation: A crystalline solid

Formal Name: 5-((3-(4-fluorophenyl)-1H-pyrazol-4-yl)methylene)-2-imino-3-(thiazol-2-yl)thiazolidin-4-one

Purity: ≥98%

Formula Markup: C16H10FN5OS2

Formula Weight: 371.4

CAS Number: 351062-08-3

Notes: Necroptosis is a regulated caspase-independent cell death mechanism that results in morphological features resembling necrosis. Serine/threonine kinase activity of the death domain receptor-associated molecule RIP1 is thought to be essential for Fas ligand–induced and tumor necrosis factor-α (TNF-α) induced necrosis.{20737} Necrostatin-7 (Nec-7) is a necroptosis inhibitor that is structurally and biologically distinct from necrostatin-1, -3, -4, and -5 as it does not inhibit RIP1 kinase. Nec-7 may target an additional regulatory molecule in this pathway as it inhibits TNF-α-induced necroptosis in a FADD-deficient variant of human Jurkat T cells with an EC50 value of 10.6 μM.{20735}

• SKU: CAY10528-5
• Manufacturer: Cayman Chemical
• Manufacturer SKU: 10528-5
• Package Unit: 5 mg
• Quantity Unit: STK