Necrosulfonamide, CAS 1360614-48-7

Product Description: Necrosulfonamide is a necroptosis inhibitor acting by selectively targeting the mixed lineage kinase domain-like protein (MLKL). Necrosulfonamide prevents MLKL-RIP1-RIP3 necrosome complex from interacting with its downstream effectors. MLKL is a critical substrate of RIP3 during the induction of necrosis[1].

Applications: Cancer-Kinase/protease

Formula: C18H15N5O6S2

References: [1]Sun L, et al. Mixed lineage kinase domain-like protein mediates necrosis signaling downstream of RIP3 kinase. Cell. 2012;148(1-2):213-227.

CAS Number: 1360614-48-7

Molecular Weight: 461.47

Compound Purity: 99.47

Research Area: Cancer

Solubility: DMSO : ≥ 28 mg/mL

Target: Mixed Lineage Kinase

• SKU: MEXHY-100573-10.1
• Manufacturer: MedChemExpress
• Manufacturer SKU: HY-100573-10.1
• Package Unit: 10 mM/1 ml
• Quantity Unit: STK