Application Note: WB: 1:1000-1:3000. *Optimal dilutions/concentrations should be determined by the researcher.Not tested in other applications.
Calculated MW: 37
Form: Liquid
Buffer (with preservative): PBS, 150mM NaCl, 50%Glycerol, 0.02% Sodium Azide.
Concentration: 1 mg/ml (Please refer to the vial label for the specific concentration.)
Background: This gene encodes a member of the Fpg/Nei family of DNA glycosylases. These glycosylases initiate the first step in base excision repair by cleaving oxidatively damaged bases and introducing a DNA strand break via their abasic site lyase activity. This enzyme is primarily associated with DNA repair during transcription and acts prefentially on cytosine-derived lesions, particularly 5-hydroxyuracil and 5-hydroxycytosine. It contains an N-terminal catalytic domain, a hinge region, and a C-terminal DNA-binding domain with helix-two-turn-helix and zinc finger motifs. This enzyme interacts with the X-ray cross complementing factor 1 scaffold protein as part of a multi-protein DNA repair complex. A pseudogene of this gene has been identified. [provided by RefSeq, Mar 2017]
Uniprot ID: Q969S2
Antigen Species: Human
Immunogen: A synthesized peptide derived from human NEIL2.
Purification: Purified by antigen-affinity chromatography
Conjugation: Unconjugated
Full Name: nei like DNA glycosylase 2
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