Product Type: Inhibitor
CAS No.: 159989-65-8
MolecularFormula: C32H45N3O4S • CH3SO3H
Molecular Weight: 663,9
Source: Synthetic
Purity: >98% (HPLC); NMR (Conforms)
Solubility: May be dissolved in DMSO (70 mg/ml)
Appearance: White powder
PubChem CID: 64142
Scientific Background: Besides being a protease inhibitor used in the therapeutic agent for acquired immunodeficiency syndrome (AIDS), it is also stimulates autophagy and and exhibits anti-cancer properties. It appears to do by inhibition of the Akt/PKB signaling pathway and activation of endoplasmic reticulum stress with subsequent unfolded protein response (1). Nelfinavir has also been shown to treat SARS-coronavirus (2), and is being tested currently to treat COVID-19.
References: 1. Koltai T., (2015). F1000Res. 4(2): 9. 2. Yamamoto N., et al. (2004) Biochem Biophys Research Comm. 318: 719-725.
Field of Use: Not for use in humans. Not for use in diagnostics or therapeutics. For in vitro research use only.
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