Product Description: Nelotanserin is a potent 5-HT2A inverse agonist, a moderately potent 5-HT2C partial inverse agonist and a weak 5-HT2B inverse agonist, with IC50s of 1.7, 79, 791 nM in IP accumulation assays, respectively.
Applications: Cancer-programmed cell death
Formula: C18H15BrF2N4O2
References: [1]Al-Shamma HA et al. Nelotanserin, a novel selective human 5-hydroxytryptamine2A inverse agonist for the treatment of insomnia. J Pharmacol Exp Ther. 2010 Jan;332(1):281-90./[2]Teegarden BR et al. Discovery of 1-[3-(4-bromo-2-methyl-2h-pyrazol-3-yl)-4-methoxyphenyl]-3-(2,4-difluorophenyl)urea (nelotanserin) and related 5-hydroxytryptamine2A inverse agonists for the treatment of insomnia. J Med Chem. 2010 Mar 11;53(5):1923-36.
CAS Number: 839713-36-9
Molecular Weight: 437.24
Compound Purity: 99.52
Research Area: Cancer; Neurological Disease
Solubility: DMSO : ≥ 32 mg/mL
Target: 5-HT Receptor
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