Product Description: Nerandomilast (BI 1015550) is an orally active inhibitor of PDE4B with an IC50 value of 7.2 nM. Nerandomilast has good safety and potential applications in inflammation, allergic diseases, pulmonary fibrosis, and chronic obstructive pulmonary disease (COPD)[1][2].
Applications: COVID-19-immunoregulation
Formula: C20H25ClN6O2S
References: [1]Pouzet P A, et al. Piperidino-dihydrothienopyrimidine sulfoxides and their use for treating COPD and asthma. United States. US9150586./[2]Herrmann FE, et al. BI 1015550 is a PDE4B Inhibitor and a Clinical Drug Candidate for the Oral Treatment of Idiopathic Pulmonary Fibrosis. Front Pharmacol. 2022 Apr 20;13:838449.
CAS Number: 1423719-30-5
Molecular Weight: 448.97
Compound Purity: 99.93
Research Area: Inflammation/Immunology
Solubility: DMSO : 10 mg/mL (ultrasonic;warming;heat to 60°C)
Target: Phosphodiesterase (PDE)
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