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Applications: Monitor norepinephrine uptake activity and screen for activators or inhibitors of NET activities in a cellular context
Background: NET is a monoamine transporter responsible for the sodium-chloride (Na+/Cl¯)-dependent reuptake of extracellular norepinephrine (NE), also known as noradrenaline. NET can also reuptake extracellular dopamine (DA). The reuptake of these two neurotransmitters is essential in regulating concentrations in the synaptic cleft. NETs, along with the other monoamine transporters, play a key role in depression and neurodegenerative diseases (NDD) such as Alzheimer's and Parkinson's disease. NET is the target of many antidepressants and recreational drugs. In addition, an overabundance of NET is associated with ADHD.
Description: Recombinant CHOK1 cell line expressing human norepinephrine transporter (NET), Genbank accession number NM_001043.
Format: Each vial contains ~2 X 10^6 cells in 1 ml of 10% DMSO
Host Cell Line: CHO-K1
Mycoplasma Testing: The cell line has been screened using the PCR-based Venor™GeM Mycoplasma Detection kit (Sigma-Aldrich, #MP0025) to confirm the absence of Mycoplasma species.
Storage Stability: Immediately upon receipt, store in liquid nitrogen.
Biosafety Level: BSL-1
References: 1. Zhou, J., Drugs Future. 2004; 29(12): 1235-1244. 2. Jorgensen, S., et al., Journal of Neuroscience methods. 2008; 169: 168-176.
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