Nevanimibe, CAS 133825-80-6

Product Description: Nevanimibe (PD-132301) is an orally active and selective acyl-coenzyme A:cholesterol O-acyltransferase 1 (ACAT1) inhibitor with an EC50 of 9 nM. Nevanimibe inhibits ACAT2 with an EC50 of 368 nM. Nevanimibe induces cell apoptosis and has the potential for adrenocortical cancer[1].

Applications: Cancer-programmed cell death

Formula: C27H39N3O

Citations: Cell Rep. 2022 Nov 29;41(9):111724./Mol Cell Endocrinol. 2024 Oct 13:112385./Structure. 2021 Sep 11;S0969-2126(21)00259-8.

References: [1]LaPensee CR, et al. ATR-101, a Selective and Potent Inhibitor of Acyl-CoA Acyltransferase 1, Induces Apoptosis in H295R Adrenocortical Cells and in the Adrenal Cortex of Dogs. Endocrinology. 2016 May;157(5):1775-88.

CAS Number: 133825-80-6

Molecular Weight: 421.62

Research Area: Cancer

Solubility: 10 mM in DMSO

Target: Acyltransferase;Apoptosis

• SKU: MEXHY-100399-10
• Manufacturer: MedChemExpress
• Manufacturer SKU: HY-100399-10
• Package Unit: 10 mg
• Quantity Unit: STK