NGI 1, CAS 790702-57-7

Shelf life (days): 1460.0

Formulation: A solid

Formal Name: 5-[(dimethylamino)sulfonyl]-N-(5-methyl-2-thiazolyl)-2-(1-pyrrolidinyl)-benzamide

Purity: ≥98%

Formula Markup: C17H22N4O3S2

Formula Weight: 394.51374

CAS Number: 790702-57-7

Notes: NGI 1 is an oligosaccharyltransferase (OST) inhibitor.{57264} It binds to and stabilizes the STT3B catalytic subunit of OST in a cellular thermal shift assay (CETSA) and inhibits N-linked glycosylation in a reporter assay using D54 ER-LucT cells (IC50 = 1.1 µM). NGI 1 (10 µM) reduces glycosylation and membrane localization of EGFR in H3255 lung adenocarcinoma cells and inhibits proliferation of PC-9 and A549 non-small cell lung cancer (NSCLC) cells. It inhibits dengue and Zika virus replication in HEK293 cells (EC50s = 0.85 and 2.2 µM, respectively).{57265} NGI 1 also reduces viral RNA in HEK293 cells infected with West Nile virus or yellow fever virus.

• SKU: CAY31519-50
• Manufacturer: Cayman Chemical
• Manufacturer SKU: 31519-50
• Package Unit: 50 mg
• Quantity Unit: STK