Nifurpirinol (Standard), CAS 13411-16-0

Nifurpirinol (Standard), CAS 13411-16-0
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MEXHY-135470R-0
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MedChemExpress

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Product Description: Nifurpirinol (P-7138) (Standard) is the analytical standard of Nifurpirinol (HY-135470). This product is intended for research and analytical applications. Nifurpirinol (P-7138) is a selective prosubstrate of bacterial nitroreductase (NTR). NTR catalyzes the reduction of nifurpirinol to generate cytotoxic metabolites that induce apoptosis in target cells. Nifurpirinol selectively ablates NTR-expressing cells such as pancreatic β cells, osteoblasts, dopaminergic neurons, and podocytes in transgenic zebrafish models. Nifurpirinol can be used in regeneration studies and disease modeling such as focal segmental glomerulosclerosis (FSGS)[1][2].

Formula: C12H10N2O4

References: [1]Bergemann D, et al. Nifurpirinol: A more potent and reliable substrate compared to metronidazole for nitroreductase-mediated cell ablations. Wound Repair Regen. 2018 Mar;26(2):238-244./[2]Klawitter M, Siegerist F, Daniel S, et al. Nifurpirinol: A potent inducer of FSGS-like glomerular injury in transgenic zebrafish[J]

CAS Number: 13411-16-0

Molecular Weight: 246.22

Research Area: Infection

Target: Bacterial;Reference Standards
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SKU MEXHY-135470R-0
Manufacturer MedChemExpress
Manufacturer SKU HY-135470R-0
Package Unit Get quote
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