Brophenexin (free base), CAS 1353979-43-7

Product Description: Brophenexin free base (compound 8) is a potent NMDAR/TRPM4 interaction interface inhibitor. Brophenexin free base shows neuroprotective activity. Brophenexin free base prevents NMDA-induced cell death and mitochondrial dysfunction in hippocampal neurons, with an IC50 of 2.1 μM. Brophenexin free base protects mice from MCAO-induced brain damage and NMDA-induced retinal ganglion cell loss[1].

Applications: Neuroscience-Neurodegeneration

Formula: C11H17BrN2

References: [1]Yan J, et al. Coupling of NMDA receptors and TRPM4 guides discovery of unconventional neuroprotectants. Science. 2020 Oct 9;370(6513):eaay3302.

CAS Number: 1353979-43-7

Molecular Weight: 257.18

Compound Purity: 99.24

Research Area: Neurological Disease

Solubility: DMSO : 100 mg/mL (ultrasonic)

Target: ERK;iGluR;TRP Channel

• SKU: MEXHY-139192A-10.1
• Manufacturer: MedChemExpress
• Manufacturer SKU: HY-139192A-10.1
• Package Unit: 10 mM/1 ml
• Quantity Unit: STK