Product Description: Nogapendekin alfa (his tag), a soluble protein subunit of a human interleukin (IL)-15 variant, is a superagonist of IL-15. Nogapendekin alfa (his tag) promotes the proliferation and viability of immune cells. Nogapendekin alfa (his tag) combines with Inbakicept (HY-P99661) at a ratio of 2:1, to form N-803 (Nogapendekin alfa inbakicept), an IL-15 cytokine antibody fusion protein. N-803 reduces tumor burden by activation of NK cells and CD8+ T cells[1].
Applications: COVID-19-immunoregulation
Formula: N/A
References: [1]Chen W, et al. ALT-803 in the treatment of non-muscle-invasive bladder cancer: Preclinical and clinical evidence and translational potential. Front Immunol. 2022 Nov 10;13:1040669.
CAS Number: 1622189-43-8
Molecular Weight: N/A
Compound Purity: 98.62
Research Area: Cancer; Inflammation/Immunology
Solubility: 10 mM in DMSO
Target: Interleukin Related
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