Product Description: Nolatrexed dihydrochloride (AG 337) is a non-competitive lipophilic inhibitor of thymidylate synthase, interacts at the folate cofactor binding site of the enzyme, with a Ki of 11 nM for human thymidylate synthase[1]. Nolatrexed dihydrochloride (AG 337) induces cell cycle arrest in S phase of cancer cells. Anti-cancer activity[2].
Applications: Cancer-programmed cell death
Formula: C14H14Cl2N4OS
References: [1]Webber S, et al. AG337, a novel lipophilic thymidylate synthase inhibitor: in vitro and in vivo preclinical studies. Cancer Chemother Pharmacol. 1996;37(6):509-17./[2]McGuire JJ, et al. Characterization of the effect of AG337, a novel lipophilic thymidylate synthase inhibitor, on human head and neck and human leukemia cell lines.
CAS Number: 152946-68-4
Molecular Weight: 357.26
Compound Purity: 98.38
Research Area: Cancer
Solubility: DMSO : 41.67 mg/mL (ultrasonic)/H2O : 50 mg/mL (ultrasonic)
Target: Thymidylate Synthase
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