NPC-15437 (hydrochloride), CAS 141774-20-1

Shelf life (days): 1460.0

Formulation: A crystalline solid

Formal Name: (2S)-2,6-diamino-N-[[1-(1-oxotridecyl)-2-piperidinyl]methyl]-hexanamide, dihydrochloride

Purity: ≥95%

Formula Markup: C25H50N4O2 / 2HCl

Formula Weight: 511.6

CAS Number: 141774-20-1

Notes: NPC-15437 is a selective protein kinase C (PKC) inhibitor (IC50 = 19 µM).{34103} It competitively inhibits phorbol ester- (Ki = 5 µM) and phosphatidylserine-induced (Ki = 12 µM) PKC activity but does not affect the activity of cAMP-dependent or Ca2+/calmodulin-dependent protein kinases. PKC signaling is involved in learning and memory, and when NPC-15437 was administered after Y maze training (0.1-10 mg/kg i.p.), it led to memory retention deficits in mice.{34102}

• SKU: CAY20212-5
• Manufacturer: Cayman Chemical
• Manufacturer SKU: 20212-5
• Package Unit: 5 mg
• Quantity Unit: STK