Target Synonym: ALPS;HRAS;NRAS;ALPS4;CMNS;N-ras;NCMS;NRAS1;NS6;GTPase NRas;GTPase;HRAS1;RASN;Transforming protein N-Ras;AV095280;N ras;N ras protein part 4;Neuroblastoma RAS viral (v ras) oncogene homolog;OTTHUMP00000013879;OTTMUSP00000023521;Transforming protein N Ras;v ras neuroblastoma RAS viral oncogene homolog
Background: This is an N-ras oncogene encoding a membrane protein that shuttles between the Golgi apparatus and the plasma membrane. This shuttling is regulated through palmitoylation and depalmitoylation by the ZDHHC9-GOLGA7 complex. The encoded protein, which has intrinsic GTPase activity, is activated by a guanine nucleotide-exchange factor and inactivated by a GTPase activating protein. Mutations in this gene have been associated with somatic rectal cancer, follicular thyroid cancer, autoimmune lymphoproliferative syndrome, Noonan syndrome, and juvenile myelomonocytic leukemia. [provided by RefSeq, Jun 2011]
Immunogen: Recombinant Human NRAS / N-Ras Protein
Buffer: 0.2 μm filtered solution in PBS
Dilution: WB 1:500-1:2000;
Calculated MW: 21 kDa
Observed MW: 21 kDa
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