NRL-1049, CAS 1973494-16-4

Product Description: NRL-1049 (BA-1049) is a ROCK2 selective inhibitor (IC50: 0.59 µM and 26 µM for ROCK2 and ROCK1 respectively). NRL-1049 reduces Lysophosphatidic acid induced ROCK activation in endothelial cells. NRL-1049 reduces lesion volume and hemorrhagic transformation in a mouse model of cavernous angiomas. NRL-1049 also preserves the BBB and suppresses seizures after brain injury, and inhibits hemorrhagic transformation after ischemic stroke in mice[1].

Formula: C16H21N3O2S

References: [1]Mulder IA, et al. The novel ROCK2 selective inhibitor NRL-1049 preserves the blood-brain barrier after acute injury. J Cereb Blood Flow Metab. 2024 Jun 4:271678X241238845.

CAS Number: 1973494-16-4

Molecular Weight: 319.42

Research Area: Neurological Disease

Target: ROCK

• SKU: MEXHY-162596-10
• Manufacturer: MedChemExpress
• Manufacturer SKU: HY-162596-10
• Package Unit: 10 mg
• Quantity Unit: STK