Shelf life (days): 1460.0
Formulation: A crystalline solid
Formal Name: N-(5-chloro-2-hydroxyphenyl)-N'-[2-chloro-5-(trifluoromethyl)phenyl]-urea
Purity: ≥98%
Formula Markup: C14H9Cl2F3N2O2
Formula Weight: 365.1
CAS Number: 501684-93-1
Notes: NS 1738 is a positive allosteric modulator of the α7-containing neuronal nicotinic acetylcholine receptors (nAChRs).{29720} When applied in the presence of ACh, NS 1738 increases the peak amplitude of the current flowing through α7-containing nAChRs (EC50 = 3.4 µM).{29720} NS 1738 displays no substantial activity for α4β2-, α3β3-, and α1-containing receptors. It is modestly brain-penetrant and counteracts (-)-scopolamine-induced deficit in acquisition of a water-maze learning task in rats.{29720} NS 1738 also improves performance in the rat social recognition test.{29720} NS 1738 is used to selectively evaluate the role of α7-containing nAChRs in signaling pathways.{33287,33288}
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