Product Description: NSC 228155 is an activator of EGFR, binds to the extracellular region of EGFR and enhance tyrosine phosphorylation of EGFR[1]. NSC 228155 is also a potent inhibitor of KIX-KID interaction, inhibits kinase-inducible domain (KID) from CREB and KID-interacting domain (KIX) from CBP, with an IC50 of 0.36 μM[2].
Applications: Cancer-Kinase/protease
Formula: C11H6N4O4S
References: [1]Sakanyan V, et al. Activation of EGFR by small compounds through coupling the generation of hydrogen peroxide to stable dimerization of Cu/Zn SOD1. Sci Rep. 2016 Feb 17;6:21088./[2]Xie F, et al. Identification, synthesis and evaluation of substituted benzofurazans as inhibitors of CREB-mediated gene transcription. Bioorg Med Chem Lett. 2013 Oct 1;23(19):5371-5.
CAS Number: 113104-25-9
Molecular Weight: 290.25
Compound Purity: 98.0
Research Area: Cancer
Solubility: DMSO : 16 mg/mL (ultrasonic)
Target: EGFR;Epigenetic Reader Domain;Histone Acetyltransferase
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