Product Description: NSC 23766 trihydrochloride is an inhibitor of Rac1 activation.
Applications: Cancer-Kinase/protease
Formula: C24H38Cl3N7
Citations: Adv Sci (Weinh). 2021 Mar 8;8(10):2004000./Am J Physiol Cell Physiol. 2022 Feb 2./Arch Toxicol. 2022 May 4./Arch Toxicol. 2022 Nov;96(11):2913-2926./CNS Neurosci Ther. 2021 Feb 3./Comput Struct Biotec. 2021;19:1933-1943./Fish Shellfish Immunol. 2022 Aug 3;S1050-4648(22)00414-4./Food Chem Toxicol. 2020 Dec 24;148:111926./Food Funct. 2021 Jan 7;12(1):154-161./Front Immunol. 02 August 2021./Front Immunol. 2021 Aug 2;12:686846./Glia. 2023 Apr 26./J Agric Food Chem. 2021 Oct 25./J Inorg Biochem. 13 January 2022, 111725./J Inorg Biochem. 2022 Apr 20;233:111838./Mol Immunol. 2022 Feb 4;143:135-146./Phytomedicine. 2024 Aug 27:134:155986./Preprints. 2024 Aug 27./Virology. 2024 Dec./Bioact Mater. 2021 Jun 1./Biochim Biophys Acta Mol Basis Dis. 2024 Mar 18;1870(4):167124./Biol Pharm Bull. 2021 Sep 1;44(9):1263-1271./Cell Death Dis. 2022 Feb 17;13(2):158./Cell Immunol. 2024 Jun 17:401-402:104843./Cell Mol Life Sci. 2024 Dec 27;82(1):28./Exp Ther Med. June 7, 2022./Int Immunopharmacol. 2023 Mar 15;117:110014./J Cell Commun Signal. 2022 Dec 12./J Cell Mol Med. 2020 Mar;24(6):3582-3592./Microsyst Nanoeng. 2024 Jul 15:10:97./Mol Cell Endocrinol. 16 July 2022, 111719./Nat Metab. 2022 Dec 19./Poult Sci/Research Square Preprint. 2020 Jul./Research Square Preprint. 2023 Sep 1./Vet Microbiol. 2022 Jun;269:109434.
References: [1]Veluthakal R, et al. NSC23766, a Known Inhibitor of Tiam1-Rac1 Signaling Module, Prevents the Onset of Type 1 Diabetes in the NOD Mouse Model. Cell Physiol Biochem. 2016;39(2):760-7./[2]Song SJ, et al. Inhibition of Rac1 GTPase activity affects porcine oocyte maturation and early embryo development. Sci Rep. 2016 Oct 3;6:34415/[3]Zhao L, et al. Rac1 modulates the formation of primordial follicles by facilitating STAT3-directed Jagged1, GDF9 and BMP15 transcription in mice. Sci Rep. 2016 Apr 6;6:23972/[4]Wang Y, et al. Involvement of Rac1 signalling pathway in the development and maintenance of acute inflammatory pain induced by bee venom injection. Br J Pharmacol. 2016 Mar;173(5):937-50
CAS Number: 1177865-17-6
Molecular Weight: 530.96
Compound Purity: 99.41
Research Area: Cancer
Solubility: DMSO : 33.33 mg/mL (ultrasonic)/H2O : ≥ 32 mg/mL
Target: Apoptosis;Ras
English
Deutsch
