Shelf life (days): 1460.0
Formulation: A crystalline solid
Formal Name: 2,3-bis[(2-hydroxyethyl)thio]-1,4-naphthalenedione
Purity: ≥98%
Formula Markup: C14H14O4S2
Formula Weight: 310.4
CAS Number: 93718-83-3
Notes: NSC 95397 is a 1,4-naphthoquinone-based irreversible inhibitor of Cdc25 dual-specificity phosphatases, with Ki values of 32, 96, and 40 nM for Cdc25A, Cdc25B, and Cdc25C, respectively.{33364} It displays >125-fold selectivity for Cdc25 over VH1-related dual-specificity phosphatase and protein tyrosine phosphatase 1b. NSC 95397 significantly inhibits the growth of human and murine carcinoma cells, blocking G2/M phase transition.{33364,17981} In rat liver epithelial cells, NSC 95397 induces cell cycle arrest, which is associated with phosphorylation of EGFR, activation of ERK1/2, phosphorylation of connexin43, and downregulation of gap junctional intercellular communication.{33365}
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