NT157, CAS 1384426-12-3

Product Description: NT157 (Tyrphostin NT157) is a selective IRS-1/2 inhibitor that induces Ser-phosphorylation and consequently the degradation of IRS-1/2. NT157 (Tyrphostin NT157) is a first-in-class anti-cancer agent that also targets Stat3 signaling pathway[1][2].

Applications: Cancer-Kinase/protease

Formula: C16H14BrNO5S

References: [1]Downregulated the Tyr-phosphorylation of IRS-1 in the MG-63 and U-2OS cells./[2]Flashner-Abramson E, et al. Targeting melanoma with NT157 by blocking Stat3 and IGF1R signaling. Oncogene. 2016 May 19;35(20):2675-80./[3]Ibuki N, et al. The tyrphostin NT157 suppresses insulin receptor substrates and augments therapeutic response of prostate cancer. Mol Cancer Ther. 2014 Dec;13(12):2827-39./[4]Ishii H, et al. miR-130a and miR-145 reprogram Gr-1+CD11b+ myeloid cells and inhibit tumor metastasis through improved host immunity. Nat Commun. 2018 Jul 4;9(1):2611.

CAS Number: 1384426-12-3

Molecular Weight: 412.26

Compound Purity: 99.38

Research Area: Cancer; Endocrinology

Solubility: DMSO : ≥ 30 mg/mL

Target: Insulin Receptor;STAT

• SKU: MEXHY-100037-10.1
• Manufacturer: MedChemExpress
• Manufacturer SKU: HY-100037-10.1
• Package Unit: 10 mM/1 ml
• Quantity Unit: STK