NU 6140, CAS 444723-13-1

Shelf life (days): 1460.0

Formulation: A crystalline solid

Formal Name: 4-[[6-(cyclohexylmethoxy)-9H-purin-2-yl]amino]-N,N-diethyl-benzamide

Purity: ≥98%

Formula Markup: C23H30N6O2

Formula Weight: 422.5

CAS Number: 444723-13-1

Notes: NU 6140 is a cyclin-dependent kinase 2 (Cdk2) inhibitor (IC50 = 0.41 μM) that demonstrates 10- to 36-fold selectivity against Cdk2-cyclin A compared to Cdk1-cyclin B, Cdk4-cyclin D, Cdk5-p25, or Cdk7-cyclin H.{28149} NU 6140 has been found to induce cell-cycle arrest at the G2-M phase and to potentiate the apoptotic effect of paclitaxel (Item No. 10461) in HeLa cells by inhibiting the anti-apoptotic protein, survivin.{28149}

• SKU: CAY17271-500
• Manufacturer: Cayman Chemical
• Manufacturer SKU: 17271-500
• Package Unit: 500 µg
• Quantity Unit: STK