NUC-1031, CAS 840506-29-8

Shelf life (days): 1460.0

Formulation: A crystalline solid

Formal Name: N-(2'-deoxy-2',2'-difluoro-P-phenyl-5'-cytidylyl)-L-alanine, phenylmethyl ester

Purity: ≥98% (mixture of diastereomers)

Formula Markup: C25H27F2N4O8P

Formula Weight: 580.474607

CAS Number: 840506-29-8

Notes: NUC-1031 is a prodrug form of the anticancer nucleoside analog gemcitabine (Item No. 11690).{43518,43517} NUC-1031 is more lipophilic than gemcitabine and enters cells through passive diffusion.{43518} It inhibits the growth of L1210, CEM, MP-2, and BxPC-3 cancer cells in vitro (IC50 = 35, 30, 60, and 40 nM, respectively).{43517} NUC-1031 (0.076 mmol/kg) reduces tumor growth in Mia-PaCa-2 and BxPC-3 mouse xenograft models, which are partially responsive and resistant to gemcitabine, respectively.{43519}

• SKU: CAY9003247-5
• Manufacturer: Cayman Chemical
• Manufacturer SKU: 9003247-5
• Package Unit: 5 mg
• Quantity Unit: STK