NVS-STG2, CAS 3030588-01-0

Product Description: NVS-STG2 is a molecular glue that targets STING and activates STING-mediated immune signaling. NVS-STG2 induces higher-order oligomerization of human STING by binding to pockets between adjacent STING dimer transmembrane domains, effectively acting as a molecular glue. NVS-STGI enhances the activity of cGAMP by inducing the formation of more abundant and larger oligomers. NVS-STG2 produces antitumor activity in animal models[1][2].

Applications: Cancer-programmed cell death

Formula: C25H33NO5

References: [1]Li J et al. Activation of human STING by a molecular glue-like compound. Nat Chem Biol. 2023 Oct 12./[2]Sulpizio A, et al. A new road to STING activation. Nat Chem Biol. 2023 Oct 13.

CAS Number: 3030588-01-0

Molecular Weight: 427.53

Compound Purity: 99.76

Research Area: cancer

Solubility: DMSO : 100 mg/mL (ultrasonic)

Target: Molecular Glues;STING

• SKU: MEXHY-157214-25
• Manufacturer: MedChemExpress
• Manufacturer SKU: HY-157214-25
• Package Unit: 25 mg
• Quantity Unit: STK