Obatoclax (mesylate), CAS 803712-79-0

Shelf life (days): 1460.0

Formulation: A crystalline solid

Formal Name: 2-[2-[(3,5-dimethyl-1H-pyrrol-2-yl)methylene]-3-methoxy-2H-pyrrol-5-yl]-1H-indole, monomethanesulfonate

Purity: ≥98%

Formula Markup: C20H19N3O / CH3SO3H

Formula Weight: 413.5

CAS Number: 803712-79-0

Notes: Obatoclax is an antagonist of Bcl-2 family members containing four Bcl-2 homology domains, including Bcl-2, Bcl-W, Bcl-xL, and Mcl-1 (Kd = ~500 nM).{24297} It prevents the interaction of these pro-survival proteins with Bax or Bak, thereby inducing apoptosis with up-regulation of Bim, induced cytochrome c release, and activation of caspase-3.{24296,16717} Obatoclax also induces autophagy in mouse embryo fibroblasts and in HeLa cells.{24298} This compound inhibits the growth of cancer cell lines and primary cancer isolates.{16717,24296}

• SKU: CAY11499-1
• Manufacturer: Cayman Chemical
• Manufacturer SKU: 11499-1
• Package Unit: 1 mg
• Quantity Unit: STK