Product Description: Oleuropein Aglycone (3,4-DHPEA-EA) is a polyphenol and the aglycone form of oleuropein (HY-N0292), formed by enzymatic, acidic or acetylated hydrolysis of oleuropein. Dietary intake of oleuropein Aglycone (50 mg/kg diet) increases the number of neuronal autophagic vesicles, reverses cognitive deficits in the TgCRND8 transgenic mouse model of Alzheimer's disease, and reduces the levels of histone deacetylase 2 (HDAC2) in the cortex and hippocampus. Oleuropein Aglycone increases urinary norepinephrine, interscapular brown adipose tissue epinephrine, and UCP1 protein levels, and reduced plasma leptin levels and total abdominal adipose tissue weight in a rat model of high-fat diet-induced obesity. Oleuropein Aglycone also reduced lung neutrophil infiltration, lipid peroxidation, and IL-1β levels in a mouse model of carrageenan-induced pleurisy.
Applications: COVID-19-immunoregulation
Formula: C19H22O8
References: [1]Xu, et al. Structure properties, acquisition protocols, and biological activities of oleuropein aglycone. Front. Chem. 6, 239 (2018).
CAS Number: 31773-95-2
Molecular Weight: 378.37
Compound Purity: 98.46
Research Area: Inflammation/Immunology
Target: Adrenergic Receptor;HDAC;α-synuclein
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