Onalespib, CAS 912999-49-6

Shelf life (days): 1460.0

Formulation: A crystalline solid

Formal Name: [1,3-dihydro-5-[(4-methyl-1-piperazinyl)methyl]-2H-isoindol-2-yl][2,4-dihydroxy-5-(1-methylethyl)phenyl]-methanone

Purity: ≥98%

Formula Markup: C24H31N3O3

Formula Weight: 409.5

CAS Number: 912999-49-6

Notes: Onalespib is a selective inhibitor of Hsp90 (IC50 = 18 nM).{18725} It induces the degradation of specific Hsp90 client proteins, including mutant EGFR, for up to seven days in tumor cell lines in vitro and up to three days in vivo.{18725,33082} Onalespib is retained in tumor xenografts and is efficacious in a range of xenograft models.{33082}

• SKU: CAY10655-1
• Manufacturer: Cayman Chemical
• Manufacturer SKU: 10655-1
• Package Unit: 1 mg
• Quantity Unit: STK