Product Description: ONC212, a fluorinated-ONC201 analogue, is a promising anti-cancer agent and also a selective agonist of GPR132. ONC212 also induces apoptosis[1].
Applications: Cancer-programmed cell death
Formula: C24H23F3N4O
References: [1]Takenobu Nii, et al. The Novel Imipridone ONC212 Induces Pronounced Anti-Leukemia Effects in Vitro and In Vivo and Is Highly Synergistic with the BCL-2 Inhibitor ABT-199. ASH. 2017./[2]Lev A, et al. Anti-pancreatic cancer activity of ONC212 involves the unfolded protein response (UPR) and is reduced by IGF1-R and GRP78/BIP. Oncotarget. 2017 Sep 12;8(47):81776-81793./[3]Wagner J, et al. Preclinical evaluation of the imipridone family, analogs of clinical stage anti-cancer small molecule ONC201, reveals potent anti-cancer effects of ONC212. Cell Cycle. 2017 Oct 2;16(19):1790-1799.
CAS Number: 1807861-48-8
Molecular Weight: 440.46
Compound Purity: 99.86
Research Area: Cancer; Endocrinology
Solubility: DMSO : 50 mg/mL (ultrasonic)
Target: Apoptosis
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