Shelf life (days): 1460.0
Formulation: A crystalline solid
Formal Name: O-methyl-N-[(2-methyl-5-thiazolyl)carbonyl]-L-seryl-O-methyl-N-[(1S)-2-[(2R)-2-methyl-2-oxiranyl]-2-oxo-1-(phenylmethyl)ethyl]-L-serinamide
Purity: ≥98%
Formula Markup: C25H32N4O7S
Formula Weight: 532.6
CAS Number: 935888-69-0
Notes: ONX 0912 is an orally bioavailable proteasome inhibitor.{28242} It potently targets the chymotrypsin-like activity of the 20S proteasome subunits β5 and LMP7 (IC50s = 36 and 82 nM, respectively).{28242} ONX 0912 inhibits the growth of multiple myeloma cells at nanomolar concentrations while not decreasing the viability of normal peripheral blood mononuclear cells at 1 µM.{28245} It blocks the growth of xenografted human multiple myeloma cells in mice when given orally.{28245} ONX 0912 has potential applications in certain types of cancer as well as other diseases that require proteasome activity.{28240,28241,28243,28244}
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